3,4-Difluoro-2-methoxyphenylacetic acid CAS:1558274-26-2

3,4-difluoro-2-methoxyphenylacetic acid is an organic compound with a specific structure and properties. Its molecular formula is C9H8F2O3 and its molecular weight is about 202.15. From the chemical structure, the compound is based on phenylacetic acid. The 3rd and 4th positions of the benzene ring are connected to fluorine atoms (-F), the 2nd position is connected to methoxy (-OCH3), and the carboxyl group (-COOH) is connected to the side chain of the benzene ring. This structure gives it unique chemical activity and physical properties. In appearance, 3,4-difluoro-2-methoxyphenylacetic acid is usually a white to off-white crystalline powder with a certain stability and regular crystal morphology.

1. Chemical stability: At room temperature, pressure and general storage conditions, 3,4-difluoro-2-methoxyphenylacetic acid exhibits good chemical stability. However, since its molecules contain carboxyl and methoxy groups, they may react in strong acid-base activities. For example, the carboxyl group will undergo a neutralization reaction under alkaline conditions to generate the corresponding carboxylate; the methoxy group may be protonated or replaced by other groups under strong acidic conditions. In addition, the fluorine atom on the benzene ring may also undergo a substitution reaction under the action of specific nucleophiles.

2. Solubility: This product is slightly soluble in water. This is because although there are polar carboxyl groups in its molecular structure, the presence of benzene rings, fluorine atoms and methoxy groups makes the overall molecule relatively weak in polarity and has limited interaction with water molecules. However, it is soluble in a variety of organic solvents, such as ethanol, acetone, and dichloromethane. This solubility feature enables it to be fully dispersed and participate in the reaction in a suitable solvent system in organic synthesis reactions, providing convenience for subsequent synthetic operations.

3. Reactivity: The reactivity of 3,4-difluoro-2-methoxyphenylacetic acid mainly comes from its carboxyl group, methoxy group and fluorine atoms on the benzene ring. The carboxyl group is acidic and can react with bases to form salts. It can also undergo esterification reactions with alcohols to form corresponding ester compounds. The methoxy group has a certain electron-donating effect, which will affect the electron cloud density on the benzene ring, thereby affecting the substitution reaction activity on the benzene ring. The oxygen atom on the benzene ring has a large electronegativity. This makes the ortho and para carbon atoms have a certain electrophilicity and easily undergo nucleophilic substitution reactions with nucleophilic reagents.