N-Hydroxyphthalimide CAS:524-38-9

N-Hydroxyphthalimide is a white to light yellow crystalline powder. It is a valuable organic compound with relatively active chemical properties. In the field of organic synthesis, it is often used as an efficient oxidation catalyst, which can promote the smooth progress of various oxidation reactions and effectively improve the reaction efficiency and selectivity. At the same time, it also plays a key role in the synthesis of pharmaceutical intermediates, helping the research and development and production of many innovative drugs, and providing strong support for the development of the pharmaceutical industry.

product details

ZhonghanProduct Overview

N-Hydroxyphthalimide (NHPI) is a compound widely used in the field of organic chemistry and plays an important role in the chemical, pharmaceutical, material and other industries.

ZhonghanStructural formula

Molecular formula	C8H5NO3
Molecular weight	163.13
Melting point	233 °C (dec.) (lit.)
Boiling point	290.19°C (rough estimate)
Density	1.64 g/cm3
Form	Powder
Color	sticky yellow
Refractive index	1.5510 (estimate)
Storage conditions	Keep in dark place, Sealed in dry, Room Temperature
Solubility	soluble in DMSO (a little), methanol (a little)
Acidity coefficient	6.10±0.20 (Predicted)
Water solubility	Slightly soluble in water
Vapor pressure	0Pa at 25℃

ZhonghanPhysical properties

1. Appearance: White to light yellow crystalline powder.

2. Melting point: 235-237°C, at this temperature, the transition from solid to liquid occurs.

3. Solubility: Slightly soluble in water, easily soluble in organic solvents such as ethanol, acetone, and dichloromethane.

ZhonghanApplication Areas

1. Organic synthesis catalyst: As an efficient organic oxidation catalyst, NHPI can activate molecular oxygen under mild conditions to achieve selective oxidation of a variety of organic compounds. For example, in the oxidation reaction of alkanes, it can be converted into corresponding important organic synthesis intermediates such as alcohols, aldehydes, and ketones, significantly improving the efficiency and selectivity of the reaction;

2. Pharmaceutical intermediates: In the pharmaceutical field, NHPI is a key intermediate for the synthesis of a variety of drugs. Using it as a raw material, compounds with antibacterial, anti-inflammatory, anti-tumor and other biological activities can be synthesized, providing an important material basis for the research and development of new drugs;

3. Materials Science: Used to synthesize high-performance polymer materials. For example, in the synthesis of high-molecular materials such as polyamide and polyester, adding NHPI can improve the thermal stability, mechanical properties and optical properties of the materials and broaden the application range of the materials.