N-Hydroxysuccinimide CAS:6066-82-6

N-Hydroxysuccinimide is a white crystalline powder. It has active chemical properties and is an indispensable key intermediate in organic synthesis. In the field of peptide synthesis, it is often used as a condensation agent to effectively promote the formation of peptide bonds and greatly improve the efficiency and quality of synthesis. At the same time, it also plays an important role in bio-coupling technology. It can accurately connect biological molecules, assist in biomedical research and development, diagnostic reagent preparation, etc., and provide solid support for life science research and pharmaceutical industry development.

product details

ZhonghanProduct Overview

N-Hydroxysuccinimide (NHS) is a compound widely used in organic chemistry and biochemistry.

ZhonghanStructural formula

Molecular formula	C4H5NO3
Molecular weight	115.09
Melting point	95-98 °C (lit.)
Boiling point	215.33°C (rough estimate)
Density	1.4769 (rough estimate)
Form	liquid or solid
Color	Transparent yellow-brown to brown
Refractive index	1.4080 (estimate)
Storage conditions	Store at +2°C to +8°C.
Solubility	soluble in DMSO (solubility in water is), methanol (trace amount)
Acidity coefficient	7.81±0.20 (Predicted)
Water solubility	SOLUBLE
Vapor pressure	0Pa at 25℃

ZhonghanPhysical properties

1. Appearance: It is white crystalline powder with stable properties, easy to store and use;

2. Melting point: 95-98℃, physical state changes will occur when reaching this temperature range;

3. Solubility: It is easily soluble in polar organic solvents such as water, alcohol, and acetone. Its good solubility enables it to play a role in a variety of reaction systems.

ZhonghanApplication Areas

1. Bioconjugation reaction: NHS is a commonly used activation reagent in bioconjugation chemistry. It is often used in combination with carbodiimide (such as EDC) to activate carboxyl groups and promote the covalent connection between biological molecules such as proteins, peptides, antibodies and other molecules (such as fluorescent markers, solid phase carriers, etc.). It is widely used in biosensors, immunoassays, targeted drug delivery and other fields;

2. Peptide synthesis: In the process of peptide chemical synthesis, NHS participates in the reaction as a condensation agent, which can effectively promote the formation of peptide bonds between amino acids, improve the synthesis efficiency and purity of peptides, and is crucial to the artificial synthesis of complex peptides and proteins;

3. Drug research and development: used to synthesize compounds with specific biological activities as drug precursors or intermediates, providing structurally diverse raw materials for the research and development of new drugs, and helping to develop more efficient and less toxic therapeutic drugs.